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Literature summary extracted from

  • Grunewald, G.L.; Caldwell, T.M.; Li, Q.; Slavica, M.; Criscione, K.R.; Borchardt, R.T.; Wang, W.
    Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor (1999), J. Med. Chem., 42, 3588-3601.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.28 3-fluoromethyl-7-(N-benzylaminosulfonyl)-1,2,3,4-tetrahydrosioquinoline
-
 Bos taurus
2.1.1.28 3-fluoromethyl-7-(N-methylaminosulfonyl)-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 3-fluoromethyl-7-aminosulfonyl-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 3-fluoromethyl-7-azido-1,2,3,4-tetrahydrosioquinoline
-
 Bos taurus
2.1.1.28 3-fluoromethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 3-fluoromethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 3-fluoromethyl-7-iodo-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 3-fluoromethyl-7-isothiocyanato-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 3-fluoromethyl-7-methanesulfonyl-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 3-fluoromethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 3-fluoromethyl-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 3-fluoromethyl-7-[N-(4-chlorophenyl)aminosulfonyl]-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.28 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.28 adrenal gland
-
 Bos taurus
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.28 0.00021
-
 3-fluoromethyl-7-iodo-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 0.00032
-
 3-fluoromethyl-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 0.00057
-
 3-fluoromethyl-7-isothiocyanato-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 0.00064
-
 3-fluoromethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 0.00066
-
 3-fluoromethyl-7-aminosulfonyl-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 0.00074
-
 3-fluoromethyl-7-[N-(4-chlorophenyl)aminosulfonyl]-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 0.0011
-
 3-fluoromethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 0.0016
-
 3-fluoromethyl-7-methanesulfonyl-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 0.0017
-
 3-fluoromethyl-7-azido-1,2,3,4-tetrahydrosioquinoline
-
 Bos taurus
2.1.1.28 0.0024
-
 3-fluoromethyl-7-(N-methylaminosulfonyl)-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 0.0065
-
 3-fluoromethyl-7-(N-benzylaminosulfonyl)-1,2,3,4-tetrahydrosioquinoline
-
 Bos taurus
2.1.1.28 0.54
-
 3-fluoromethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus